Peripheral Blood Stem Cell Mobilisation with Pegylated Granulocyte
Colony Stimulating Factor in Children
Abstract
Aim:We report here our experience of using pegylated granulocyte colony
stimulating factor (peg-GCSF) for peripheral blood stem cell (PBSC)
mobilisation in children. Methods: A total of 9 children suffering from
high-risk/relapsed solid tumors were mobilised with chemotherapy and
peg-GCSF (100 microgram/kg single dose). Mean age was 7.7years (range
2-15 years). Results:The mean time from peg-GCSF administration to PBSC
harvest was 9.7 days. Adequate stem cells (median dose 26.9 million/kg)
could be harvested in all children by a single apheresis procedure. No
major adverse events observed. Conclusion: It is feasible and safe to
mobilise PBSC with peg-GCSF in children with cancer.