Lipoprotein X hyperlipidemia in patients with liver graft-versus-host
disease post-hematopoietic stem cell transplantation in Chinese children
- Wilson Chan
, - Eric Law,
- Tsz-Ki Ling,
- Felix Wong,
- Daniel Ka Leung Cheuk,
- Joanna Tung
Abstract
Severe hypercholesterolemia mediated by graft-versus-host disease of
liver in patients underwent allogeneic hematopoietic stem cell
transplantation is a recognized yet overlooked phenomenon. Reports in
literature is limited in both adult and pediatric population and none
had been reported in Chinese children to date. As lipoprotein X
hypercholesterolemia is due to regurgitation of cholesterol and bile
salts into systemic circulation rather than overproduction by
hepatocytes, usage of statins to downregulate cholesterol synthesis is
not effective. Here we report 2 local cases to increase awareness of
transplant physicians and endocrinologists of this association and avoid
unnecessary and ineffective usage of statins.