Evaluation of Regular Insulin Adsorption to Polypropylene Bag and
Polyvinyl Chloride Infusion Set
Abstract
Aim Clinical application of insulin infusion therapy is usually
accomplished with regular human insulin. It is known that the regular
insulin adsorbed to the hydrophobic surfaces and different approaches
were implemented into the clinical practices. It was aimed to evaluate
the rate of adsorption of insulin to PP bags and PVC infusion sets and
stability of insulin during the infusion. Methods 100 IU insulin was
added to PP bags containing 100 ml of 0.9% NaCl solution(n = 6). The
infusion was started at a rate of 2 ml/h using infusion sets in the PVC
structure. Insulin quantification was performed in the samples taken
both from the bag and from the end tip of the infusion set during
infusion. The stability of insulin solutions stored at room (+24°C) and
refrigerator (+4°C) temperatures were compared. Samples were analyzed
using reverse-phase high-performance liquid chromatography. Results No
statistically significant difference was found between the
concentrations of the samples taken from the bags stored at room and
refrigerator temperatures at the 4th, 12th, and 24th hours
(p>0.05). It was seen that the adsorption rate of insulin
to PVC set was 57% and PP bags is at most 5% at the 24th hour.
Conclusion When PP bags are used for insulin infusion, it is predicted
that 24-hour change can be made instead of frequent change. In addition,
losses caused by the high rate of insulin adsorption to PVC infusion
sets should be considered and PP infusion sets would be the better
option to use if available.