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IgE sensitisation predicts threshold but not anaphylaxis during oral food challenges to cow's milk
  • +4
  • Paul Turner,
  • Bettina Duca,
  • Sophia Chastell A,
  • Olaya Alvarez,
  • Raphaelle Bazire,
  • Marta Vazquez-Ortiz,
  • Pablo Rodriguez del Rio
Paul Turner
Imperial College London

Corresponding Author:[email protected]

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Bettina Duca
Imperial College London
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Sophia Chastell A
Imperial College London
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Olaya Alvarez
Complexo Hospitalario Universitario A Coruna
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Raphaelle Bazire
Hospital Infantil Universitario Nino Jesus
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Marta Vazquez-Ortiz
Imperial College London
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Pablo Rodriguez del Rio
Hospital Infantil Universitario Nino Jesus
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Abstract

Predicting reaction threshold and severity are important to improve the management of food allergy, however the determinants of, and relationship between, these parameters are significant knowledge gaps. Identifying robust predictors could enable the reliable risk-stratification of food-allergic individuals. In this series of young people with CM-allergy undergoing DBPCFC – the largest reported in the literature – we did identify any baseline marker which predicted the occurrence of anaphylaxis at challenge, consistent with existing data. 1 There is one report of IgE-sensitisation being predictive of severity in CM-allergy, 5 however the authors included non-reactive patients in their analysis which significantly skewed the analyses, resulting in misleading conclusions. 6 IgE-sensitisation in our cohort, particularly to casein, was predictive of LOAEL. Including an assessment of casein IgE may therefore be of clinical utility when evaluating patients with CM-allergy in the clinical setting.
08 Nov 2021Submitted to Allergy
09 Nov 2021Submission Checks Completed
09 Nov 2021Assigned to Editor
10 Nov 2021Reviewer(s) Assigned
23 Nov 2021Review(s) Completed, Editorial Evaluation Pending
30 Nov 20211st Revision Received
30 Nov 2021Submission Checks Completed
30 Nov 2021Assigned to Editor
01 Dec 2021Reviewer(s) Assigned
02 Dec 2021Review(s) Completed, Editorial Evaluation Pending
02 Dec 2021Editorial Decision: Accept
07 Dec 2021Published in Allergy. 10.1111/all.15195