Drug–drug interactions may be a serious issue for COVID-19-infected patients needed kinds of conminant medications. voriconazole and lopinavir/ritonavir were involved in interaction with cytochrome P450 enzymes, Therefore, coadministration of voriconazole and lopinavir/ritonavir is estimated to interfere the effect of voriconazole. However, the gene polymorphisms make these interactions more complicating.