The correlation of monocyte to high-density lipoprotein ratio with uric
acid and possible atherosclerotic pathway in patients treated with
isotretinoin
Abstract
Purpose: We aimed to reveal the relationship of uric acid with MHR and
other inflammatory markers acne patients before and after isotretinoin
treatment. In this way, we can try to shed light on the relationship
between isotretinoin treatment and atherosclerosis. Methods: Two hundred
twenty-four acne patients who administered isotretinoin (0.5-1
mg/kg/day) were enrolled in the study. In the pre-treatment phase and 3
months after treatment, MHR, SUA, mean platelet volume, plateletcrit,
neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio,
monocyte-lymphocyte ratio, serum triglyceride, total cholesterol,
high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels
of the patients were analyzed. Results: Compared to the pre-treatment
phase, three months after treatment, there was a statistically decrease
in neutrophil count and an increase in lymphocyte count (p: 0.002, p:
0.011; respectively). Accordingly, there was a statistically significant
decrease in NLR (p: 0.001). It was noteworthy that MHR and SUA levels
increased significantly (p: 0.042, p: 0.010; respectively) and there was
a positive correlation between SUA level and MHR (r: 0.212, p: 0.012).
Serum total cholesterol, LDL, and triglyceride levels increased and HDL
levels decreased significantly after treatment (p: 0,001). Conclusion:
This study contributes to the comprehension of the relationship between
isotretinoin treatment and atherosclerosis, which has been frequently
reported in the literature. It was thought that the isotretinoin-induced
uric acid increase might be related to dyslipidemia. Isotretinoin may
initiate the atherosclerotic process in vascular endothelial and smooth
muscles, with uric acid increase and HDL decrease. An increase in MHR is
also an inflammatory marker indicating this process.