THE EFFECTS OF VITAMIN B12, VITAMIN D, FERRITIN LEVEL,
NEUTROPHIL/MONOCYTE RATIO AND SOME BLOOD PARAMETERS ON GENITAL WARTS
PRESENCE, THE NUMBER OF LESIONS, AND RECURRENCE
Abstract
Objective Human Papillomavirus (HPV) that is an epitheliotropic virus
that infects basal keratinocytes on epithelia of skin and mucosal
membranes has been isolated in genital warts (GWs). The relationships
between cancer caused by HPV and some vitamins such as B12 and vitamin D
and iron metabolism, as well as leukocytes and their ratios have been
investigated in the literature. Our aim is to evaluate these
relatioships at the level of GW as well as to analyse if there is a
relationship between the investigated parameters and lesion numbers.
Materials and Methods Data were obtained from 98 and 94 patients for
group 1 and 2, including GW patients and healthy people, respectively.
The blood parameters and lesion numbers in the GW patients were reported
and analysed in terms of vitamin B12 and D, ferritin and leucocytes.
Results A correlation was established between lesion numbers, age and
midcorpusculer volume (MCV) (p<0.05). There was no any
correlation between lesion numbers and recurrent cases. According to the
comparative analysis, there were a difference in terms of ferritin,
neutrophil, monocyte, hemoglobine, MCV and neutrophil/monocyte ratio
between groups. The cutoff values for neutrophil, monocyte and N/M
ratios were 56.45, 4.91, and 7.825, respectively Conclusion While our
study showed that GW development may be affected by blood ferritin
levels and in this situation, MCV, neutrophil, monocyte and N / M ratios
may change, a relation was found between lesion numbers and age and mean
MCV values only. However, further studies are needed to clarify this
issue.