Abstract
Objective: To investigate the causes of early COVID-19 complicated with
platelets(PLT) abnormality, and to analyze the possible mechanisms.
Methods: The case datum of early COVID-19 complicated with PLT increase
or decrease was collected. (125-350) ×109/L defined as the normal level
of PLT(Group C), <125×109/L was defined as the PLT decrease
group (Group A), >350×109/L defined as the PLT increase
group (Group B) . The data were analyzed after collected. Results: Our
statistical results showed that the incidence of COVID-19 combined PLT
decreased was about 11.94% and the incidence of combined PLT increased
was about 9.33% at admission. Compared with Group B and C, Group A
showed a significant decrease in white blood cell, neutrophil and CD4
(P<0.05). The lymphocyte in Group A and C decreased
significantly, but not find in Group B (P<0.05). Compared with
Group A and C, IL-4 was increased in Group B, but lymphocyte decline was
not significant (P>0.05). Conclusion: PLT abnormalities
occur in all patients with different types of COVID-19. It may be
related to the severity of inflammation and infection, immune regulation
and megakaryocyte function, etc.