Thiol -- disulphide homeostasis as a novel oxidative stress marker in
pulmonary thromboembolism
Abstract
Aim of Study: Our aim is to compare dynamic thiol/disulphide homeostasis
between patients with acute pulmonary thromboembolism (PTE) and healthy
controls. Methods: Our study included 45 patients who were diagnosed
with acute PTE and 50 healthy controls. Serum thiol/disulphide was
measured. Results: We found that the native thiol, total thiol, native
thiol/total thiol levels were significantly lower in the patient group
than the control group, while the disulphide, disulphide/natural thiol,
disulphide/total thiol levels were significantly higher. Conclusion: We
have seen that in patients diagnosed with acute PTE, the
oxidant-antioxidant balance shifts towards the oxidative direction. The
disulfide/natural thiol ratio can be considered as an oxidative stress
parameter in acute PTE. We think that the deterioration in thiol
disulfide balance, together with clinical, laboratory and radiological
findings, may have diagnostic value in acute PTE patients.