Farmlands contamination with heavy metals (HMs) can be considered as a global issue especially in developing countries. The current study investigates the various pollution indices, potential ecological risk index (PERI) and human health risk caused by HMs in some selected regions of Punjab Province, Pakistan. Farmlands soil samples were collected, acid extracted and analyzed via ICP-MS (Agilent 7500c) for selected HMs. All the HMs were found within permissible limits set by worldwide regulatory authorities except Cd which exceeded its limit in 68% agricultural soils of the study area. The CF values for Cd showed high (CF≥6) degree of contamination to considerable contamination (3≤CF≤6). The CD values indicated low (CD≤6) contamination to moderate (6dermal>inhalation. Furthermore, the RI values were observed higher than 1.0×10–4 for Cd (Lahore and Faisalabad regions) and Cr (Multan and Faisalabad regions) in children working in farmlands and likely exposed to high cancer risk. So, minimization of pollutants must be the top priority of the state to reduce contaminants inputs and immobilization in soil through environmental protection laws and regulations