loading page

G Protein-Coupled Purinergic P2Y Receptor Oligomerization: Pharmacological Changes and Dynamic Regulation
  • +3
  • Xiaoqing Guo,
  • Qin Li,
  • Shulan Pi,
  • Bo Hu,
  • Yuanpeng Xia,
  • Ling Mao
Xiaoqing Guo
Huazhong University of Science and Technology

Corresponding Author:[email protected]

Author Profile
Qin Li
Huazhong University of Science and Technology
Author Profile
Shulan Pi
Huazhong University of Science and Technology
Author Profile
Bo Hu
Huazhong University of Science and Technology
Author Profile
Yuanpeng Xia
Huazhong University of Science and Technology
Author Profile
Ling Mao
Huazhong University of Science and Technology
Author Profile

Abstract

P2Y receptors (P2YRs), a δ group of rhodopsin-like G protein-coupled receptors (GPCRs), have many essential functions in physiology and pathology, such as platelet aggregation, immune responses, neuroprotective effects, inflammation, and cellular proliferation; thus, they are among the most researched therapeutic targets for use in the clinical treatment of diseases (e.g., clopidogrel, an antithrombotic drug, and Prolacria, a treatment for dry eye). Over the past two decades, GPCRs have been revealed to transmit signals as dimers to increase the diversity of signalling pathways or pharmacological activities. Many studies have frequently confirmed dimerization between P2YRs and other GPCRs due to their functions in cardiovascular and cerebrovascular processes in vivo and in vitro. Recently, some P2YR dimers that dynamically balance physiological functions in the body were shown to be involved in effective signal transduction and exert pathological pharmacological effects. In this review, we summarize the types, pharmacological changes, and active regulators of P2YR-related dimerization. In summary, our review delineates that P2YR-related dimers have new functions and pharmacological activities and maybe a novel direction to improve the effectiveness of medications such as thrombotic events associated with COVID-19.
Oct 2021Published in Biochemical Pharmacology volume 192 on pages 114689. 10.1016/j.bcp.2021.114689