Decreased Severity and Incidence of SARS-CoV-2 infection in younger
patients with bone marrow failure: Description of 4 clinical cases.
Abstract
The Coronavirus Disease 2019 pandemic, caused by the severe acute
respiratory syndrome-associated coronavirus (SARS-CoV-2), is having
devastating effects on every country around the world. SARS-CoV-2 can be
fatal in patients with described risk factors. A question remains as to
whether other immunosuppressed populations are at risk for severe
complications. There is limited data on the impact of COVID-19 in young
patients with bone marrow failure syndromes (BMFs). 29 institutions,
from the NAPAAC consortium, reported 4 with BMFs diagnosed with
SARS-CoV-2. These patients presented with relatively mild clinical
courses, raising questions as to why this apparently low morbidity and
mortality