Impaired In-vitro Platelet Aggregation and Secretion Tests in Children
with Henoch-schöenlein Purpura
Abstract
Abstract Aim: This study aimed to investigate the in-vitro platelet
aggregation and secretion tests in children patients with
Henoch-schöenlein Purpura that recently referred to as Ig A vasculitis
Methods: This is a cross-section study that included 55 patients with
Henoch-schöenlein Purpura and 31 healthy children as a control group.
Children who have a history of drug use, chronic diseases, and bleeding
diseases were excluded from the study. Complete blood count, thrombocyte
aggregation, and secretion tests were studied in both groups. These
tests were re-evaluated in remission of the disease. Results: It was
found that epinephrine-stimulated platelet aggregation and collagen,
epinephrine, ristocetin, arachidonic acid, standard dose thrombin, and
high dose thrombin-stimulated platelet secretion results were lower in
the patients with Henoch-schöenlein Purpura compared to the healthy
control group in the acute period (respectively P=0.014, 0,003; 0,003;
0,027; 0,034; 0,010; 0,049). When the values of patients with
Henoch-schöenlein Purpura in the acute period and the remission of the
disease were compared, collagen-stimulated platelet aggregation and
epinephrine-stimulated platelet secretion values were found to be lower
in patients with patients in the acute period (P= 0.016; 0.039)
Conclusion: Impairment in vitro platelet aggregation and secretion tests
in the patients with Henoch-schöenlein Purpura suggest that the tendency
to bleeding in these patients may be due to platelet impairment
function. Key Words: Henoch-schöenlein Purpura, platelet aggregation
tests, platelet secretion tests, children, Ig A vasculitis. What’s
already known about this topic? There is a tendency to bleeding in
Henoch Shcöenlein Purpura patients, such as gastrointestinal bleeding,
nonthrombocytopenic system purpura. What does this article add? It was
found that impairment in-vitro platelet aggregation and secretion tests
in Henoch Shcöenlein Purpura patients.