Abstract Concurrent presentation of MS and congenital ichthyosis is extremely rare. In this study we present a case of a 27-year-old woman with congenital ichthyosis who presented with signs of multiple sclerosis. This concurrence may provide insight into any common immunopathologic and genetic mechanisms.

Rituximab use in multiple sclerosis has been promising. Cytokine release syndrome (CRS) is a common side effect of rituximab in patients with lymphoma. We report a case of a 44-year-old man with a history of relapsing-remitting multiple sclerosis, who presented with signs and symptoms consistent with CRS after rituximab initiation.