Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio as a
risk factor for mortality in peruvian adults with chronic kidney
disease.
Abstract
Objective: To assess the association between NLR and PLR with all-cause
mortality in Peruvian patients with CKD Methods: We conducted a
retrospective cohort study in adults with CKD in stages 1 to 5. The
outcome variable was mortality and as variables of exposure to NLR and
PLR. Both ratios were categorized as high with a cut-off point of 3.5
and 232.5; respectively. We carried out a Cox regression model and
calculated crude and adjusted hazard ratios (HR) with their 95%
confidence interval (95%CI). Results: We analyzed 343 participants with
a median follow-up time of 2.45 years (2.08-3.08). The frequency of
deaths was 17.5% (n=60). In the crude analysis, the high NLR and PLR
were significantly associated with all-cause mortality (HR=2.01; 95%
CI:1.11-3.66) and (HR=2.58; 95% CI:1.31-5.20). In the multivariate
model, after adjusting for age, sex, serum creatinine, CKD stage,
albumin and hemoglobin, the high NLR and PLR remained as an independent
risk factor for all-cause mortality, (HR=2.10; 95% CI:1.11-3.95) and
(HR=2.71; 95% CI:1.28-5.72). Conclusion: Our study suggests the
relationship between high NLR and PLR with all-cause mortality in
patients with CKD.