Efficacy of combination therapy with biofeedback and dapoxetine in
lifelong premature ejaculation treatment: A prospective randomized study
Abstract
Aims: Premature ejaculation (PE) is a common sexual dysfunction that
significantly affects the quality of life of the patient and their
partner. We aimed to compare efficacy and safety of the combination
therapy with biofeedback-guided pelvic floor exercise therapy (BFT) and
dapoxetine 30 mg. Results: Patients were divided into three groups as
BFT, dapoxetine 30 mg and combination with BFT and dapoxetine 30 mg. The
patients were compared with the intravaginal ejaculatory latency time
(IELT) pre-treatment and post-treatment 1st and 3rd months. The mean
IELTs of the patients in Group 1 were 40 sec in pre-treatment, 115 sec
at the end of the 4th week and 140 sec at the end of the 12th week. The
IELT values of the patients in Group 2 were 40 sec in pre-treatment, 145
sec in the 4th week and 170 sec in the 12th week . The IELT values were
calculated in Group 3 as 42.5 sec in pre-treatment, 185 sec in the 4th
week and 205 sec in the 12th week When the IELT was statistically
compared between the groups at 1st and 3rd months, the duration in
combination group was found to increase significantly (p <
0.001). Discussion: Pelvic floor muscles play an important role in
sexual function. Rehabilitation of pelvic floor muscles provides
two-stage efficiency with electrostimulation and physiokinesitherapy; it
aims to improve the contractile forces of the perineal muscles and
increase the urethral sphicter closure force. Besides, the
rehabilitation of pelvic floor muscles allows patients to control the
contractions of the right muscle group accompanied by biofeedback
Conclusion: Combination therapy with BFT and dapoxetine 30 mg in
lifelong PE treatment is a good alternative with low side effect profile
and acceptable continuous efficiency