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Ashley Duty
Pharmacist at Children's Mercy
Kansas City, Missouri
Public Documents
1
Successful rechallenge after etoposide infusion related adverse drug reactions
Emma Tillman
and 5 more
February 12, 2021
Etoposide is an antineoplastic agent widely used for treatment of many pediatric cancers and associated with infusion related adverse drug reactions (ADRs). In this brief report we describe etoposide infusion related ADRs that occurred over a 10-year period at two freestanding pediatric hospitals. Infusion reactions occurred in 1% of patients. Of the 32 patients that experienced adverse reactions, 41% were rechallenged after the reaction and all were able to tolerate at least one future dose with either pre-treatment or extending infusion duration.