Essential Site Maintenance: Authorea-powered sites will be updated circa 15:00-17:00 Eastern on Tuesday 5 November.
There should be no interruption to normal services, but please contact us at [email protected] in case you face any issues.

loading page

3D-speckle-tracking echocardiography correlates with CMR diagnosis of acute myocarditis
  • +6
  • Philip Goody,
  • Sebastian Zimmer,
  • Angela Zimmer,
  • Jens Kreuz,
  • Marc Becher,
  • Alexander Isaak,
  • Georg Nickenig,
  • Christoph Hammerstingl,
  • Vedat Tiyerili
Philip Goody
Heart Center Bonn, University Hospital Bonn

Corresponding Author:[email protected]

Author Profile
Sebastian Zimmer
Heart Center Bonn, University Hospital Bonn
Author Profile
Angela Zimmer
Heart Center Bonn, University Hospital Bonn
Author Profile
Jens Kreuz
Author Profile
Marc Becher
Heart Center Bonn, University Hospital Bonn
Author Profile
Alexander Isaak
University Hospital Bonn
Author Profile
Georg Nickenig
Heart Center Bonn, University Hospital Bonn
Author Profile
Christoph Hammerstingl
Zentrum für Herz- und Gefäßmedizin, Mediapark Köln
Author Profile
Vedat Tiyerili
Heart Center Bonn, University Hospital Bonn
Author Profile

Abstract

Abstract Background: The diagnostic importance of three-dimensional (3D) speckle-tracking strain-imaging echocardiography in patients with acute myocarditis has not yet been assessed. The aim of this study was to test the sensitivity and specificity of 3D-speckle-tracking echocardiography as compared to CMR (cardiovascular magnetic resonance imaging) for the diagnosis of acute myocarditis. Methods and Results: 45 patients that were admitted to the Medical Clinic II of the University Hospital Bonn with clinically suspected myocarditis were enrolled in our study (71% male, mean age: 43.9±16.3 years, peak troponin level: 1.38±3.51 ng/ml). 3D full-volume echocardiographic images were obtained and offline speckle-tracking analysis of regional and global LV deformation was performed. All patients received CMR scans and myocarditis was diagnosed in 29 subjects. The 16 patients, in whom myocarditis was excluded by CMR, served as controls. Regional changes in myocardial texture and tissue edema (diagnosed by CMR) were significantly associated with regional impairment of circumferential, longitudinal, and radial strain, as well as regional 3D displacement and total 3D strain. The 3D diastolic strain index was not associated with pathological findings in the CMR. However, the 3D global longitudinal strain (GLS) outperformed well-known 2D parameters associated with myocarditis, such as LVEF and LVEDV. Conclusions: This is the first study examining the use of 3D-speckle-tracking echocardiography in patients with acute myocarditis. Global longitudinal strain was significantly associated with and impaired in patients with myocarditis. Therefore, 3D echocardiography could become a useful diagnostic tool in the primary diagnosis of myocarditis.