Coronavirus disease (COVID-2019) causes respiratory and systemic disease, has led to a sudden epidemic that affects people of all ages. The presence of cardiovascular comorbidities is associated with a higher risk of death. Therefore, patients with congenital heart disease represent a high risk population. When respiratory failure develops and mechanical ventilation is not sufficient due to Covid 19, extracorporeal membrane oxygenation (ECMO) may use as a form of rescue therapy. In this article, we present a newborn who required ECMO support for acute respiratory failure in the early postoperative period due to coronavirus 2 (SARS-CoV-2) after the aortic arch repair and ventricular septal defect closure operation. To the best of our knowledge, this patient was the first neonate case of SARS-CoV-2 infection after congenital heart surgery and was the youngest patient to receive ECMO support.