Essential Site Maintenance: Authorea-powered sites will be updated circa 15:00-17:00 Eastern on Tuesday 5 November.
There should be no interruption to normal services, but please contact us at [email protected] in case you face any issues.

loading page

Utilization of two- and three-dimensional transesophageal echocardiography in successfully guiding transcatheter mitral valve in bioprosthetic mitral valve/mitral ring implantation without complications in patients with thrombus in left atrium/left atrial appendage.
  • +7
  • Zeyad Elmarzouky,
  • Ming-Chon Hsiung,
  • Amr Darwish,
  • Subash Dulal,
  • Bhanu Maturi,
  • Wei-Hsian Yin,
  • Yung-Tsai Lee,
  • Tien-Ping Tsao,
  • Jeng Wei,
  • Navin Nanda
Zeyad Elmarzouky
Division of Cardiology Department of Medicine University of Alabama at Birmingham Birmingham Alabama USA

Corresponding Author:[email protected]

Author Profile
Ming-Chon Hsiung
Division of Cardiology Cheng Hsin General Hospital Taipei Taiwan
Author Profile
Amr Darwish
Division of Cardiology Department of Medicine University of Alabama at Birmingham Birmingham Alabama USA
Author Profile
Subash Dulal
Division of Cardiology Department of Medicine University of Alabama at Birmingham Birmingham Alabama USA
Author Profile
Bhanu Maturi
UAB Montgomery Internal Medicine Residency Program Montgomery Alabama
Author Profile
Wei-Hsian Yin
Division of Cardiology Cheng Hsin General Hospital Taipei Taiwan
Author Profile
Yung-Tsai Lee
Division of Cardiology Cheng Hsin General Hospital Taipei Taiwan
Author Profile
Tien-Ping Tsao
Division of Cardiology Cheng Hsin General Hospital Taipei Taiwan
Author Profile
Jeng Wei
Division of Cardiology Cheng Hsin General Hospital Taipei Taiwan
Author Profile
Navin Nanda
Division of Cardiology Department of Medicine University of Alabama at Birmingham Birmingham Alabama USA
Author Profile

Abstract

Background. The presence of thrombus in the left atrial appendage (LAA) and/or LA body has so far been considered a contraindication to the transcatheter mitral valve (MV) in bioprosthetic MV/ MV annuloplasty ring implantation. Objective. The aim of this study is to describe, for the first time to our knowledge, the utilization of both two-dimensional (2D) and three-dimensional (3D) transesophageal echocardiography (TEE) in successfully performing without any embolic or other complications transcatheter MV in bioprosthetic MV/ mitral ring implantation using the apical approach in a group of 12 patients (pts) with co-existing LAA and/or LA body thrombus. Patients, Methods and Results. All pts were severely symptomatic with severe bioprosthetic MV stenosis in 9, severe native MV stenosis with a previous surgically inserted MV annuloplasty ring in 1 and severe MV regurgitation secondary to bioprosthetic cusp rupture in 2 pts. Thrombus in the LAA and/ or LA body was noted in all pts by 2D and 3DTEE. All pts were at high or prohibitive risk for surgery and all refused surgery. Utilizing both 2D and 3DTEE, especially 3DTEE, the guidewires and the prosthesis deployment system could be manipulated under direct vision through the MV bioprosthesis into the LA and left superior pulmonary vein bypassing and avoiding any contact with the thrombus. The transcatheter procedure was successfully accomplished in all patients with relief of stenosis/ regurgitation and amelioration of symptoms with no embolic or other complications during the procedure and over a mean follow-up period of 21 months. Conclusion. Our small study demonstrates the feasibility of successfully performing transcatheter MV in bioprosthetic MV/ MV annuloplasty ring procedure in pts with thrombus in LAA and/or LA body without any embolic or other complications.