Abstract

Aging is an inevitable process caused by the accumulation of degenerative destructions, which ultimately leads to organism death. As the aging process occurs at the molecular, cellular, and tissue levels, understanding the whole details is the prerequisite for the development of anti-aging therapy. More than 300 compounds of different sources have been reported with the anti-aging activity that slow aging and extend lifespan through regulating single or multiple signaling pathways. Recent innovations in nanotechniques could lead to the development of nanomaterials having anti-aging effects or acting as nanocarrier systems and distributers of anti-aging drugs. In this review, we summarized the molecular mechanisms of longevity and the prospect of developing anti-aging nanomaterials targeting aging pathways.