Gut microbiota and bronchopulmonary dysplasia
- Kun Yang,
- Shasha He,
- WENBIN DONG
Shasha He
The Affiliated Hospital of Southwest Medical University
Author ProfileWENBIN DONG
The Affiliated Hospital of Southwest Medical University
Author ProfileAbstract
Bronchopulmonary dysplasia is a relatively common and severe
complication of prematurity, and its pathogenesis remains ambiguous.
Revolutionary advances in microbiological analysis techniques, together
with the growing sophistication of the gut-lung axis hypothesis, have
resulted in more studies linking gut microbiota dysbiosis to the
occurrence and development of bronchopulmonary dysplasia. The present
article builds on current findings to examine the intrinsic associations
between gut microbiota and bronchopulmonary dysplasia. The gut
microbiota affects bronchopulmonary dysplasia via several potential
mechanisms including alteration of the gut-lung axis, promotion of
inflammation and the ensuing growth effects, therefore these are also
investigated. By evaluating the potential mechanisms, new therapeutic
targets and potential therapeutic modalities for BPD can be identified
from a microecological perspective.18 Mar 2021Submitted to Pediatric Pulmonology 19 Mar 2021Submission Checks Completed
19 Mar 2021Assigned to Editor
19 Mar 2021Reviewer(s) Assigned
01 Apr 2021Review(s) Completed, Editorial Evaluation Pending
03 Apr 2021Editorial Decision: Revise Major
02 May 20211st Revision Received
03 May 2021Submission Checks Completed
03 May 2021Assigned to Editor
03 May 2021Reviewer(s) Assigned
14 May 2021Review(s) Completed, Editorial Evaluation Pending
16 May 2021Editorial Decision: Accept
Aug 2021Published in Pediatric Pulmonology volume 56 issue 8 on pages 2460-2470. 10.1002/ppul.25508