Here, we present 76-year-old woman, who presented with a history of quadriparesis from three years ago, initially in the lower extremities and ascended towards the upper extremities (symmetrical and progressive). Magnetic resonance imaging revealed bilateral thalamic lesions (Figure 1), which could identify it as a variant of Creutzfeldt-Jakob disease.

A 36-year-old male with non-lesional refractory frontal-lobe epilepsy, diagnosed at 16 years of age, and with a history of four hospitalizations for refractory status epilepticus and admitted to the intensive care unit with focal seizures in the right upper limb, impaired consciousness, and recurrent progression to bilateral tonic-clonic seizures.