Abstract
Since the start of the novel coronavirus SARS-Cov-2 pandemic, a disease
that has become one of the world’s greatest global health challenges,
the role of the immune system has been at the forefront of scientific
studies. The pathophysiology of COVID-19 is complex, which is evident by
those at higher risk for poor outcome. Multiple systems contribute to
thrombosis and inflammation seen in COVID-19 patients, including
neutrophil dysfunction, platelet activation, endothelial cell
activation. Understanding how the immune system functions in different
patient cohorts (particularly given recent emerging events with the
Oxford/AstraZeneca vaccine) is vital to understanding the
pathophysiology of this devastating disease and for subsequent
development of novel therapeutic targets and expedite possible drug
repurposing strategies that could benefit society on a global scale.