Endomyocardial fibrosis is a disease that causes restrictive cardiomyopathy, it varies in presentation ranging from asymptomatic to full-blown heart failure. its pathogenesis is poorly understood and it poses a diagnostic and treatment challenge due to its infrequent occurrence.

We report a case of a 35-years-old Lebanese pregnant lady with a background of beta-thalassemia major who was diagnosed with COVID-19 infection (Cycle threshold value 18) during her 23rd gestational week. Unfortunately, the pregnancy outcome was unfavorable. To our knowledge, this is the first report of such a case