Objective: Malnutrition is associated with poor clinical outcomes in many diseases. The Controlling Nutritional Status (CONUT) is an objective index used for evaluating nutritional status of hospitalized patients. The aim of this study was to investigate the relationship between malnutrition assessed by CONUT score and the prognosis in patients undergoing carotid artery stenting (CAS). Methods: The study included 170 patients who underwent CAS due to symptomatic or asymptomatic severe carotid artery stenosis. Median follow-up period was 50 (interquartile range [IQR], 41-60) months. Patients were divided into two groups according to the CONUT score: (i) normal nutrition (<2) and (ii) malnutrition (≥2). Primary endpoint was accepted as MACE (major adverse cardiac events) including all-cause death and ischemic stroke. Results:The prevalence of MACE was significantly higher in the malnutrition group (p=0.001). Kaplan Meier analysis showed lower survival rates in the malnutrition group (log rank = 9.36, p=0.002; Figure 4). In multivariate logistic regression analysis, age and CONUT score were independent predictors of all-cause death and stroke after adjustment for confounding factors, respectively, (OR: 1.058, 95% CI: 1.013-1.105, p=0.011, OR: 1.318, 95% CI: 1.017-1.881, p=0.039). Conclusion: Higher CONUT scores were associated with adverse outcomes in patients with CAS. Malnutrition assessed by the CONUT score may provide valuable prognostic information in patients with CAS.

Objective: Development of chronic total occlusion (CTO) consists of multiple histological stages, with each stage containing different histopathological features. The monocyte to high-density lipoprotein ratio (MHR) is a useful marker of the degree of inflammatory response. The aim of this study was to investigate the relationship between MHR and long-term survival and mortality in CTO patients. Methods: The study included 493 CTO patients that were followed over a period of 73 months between January 2011 and December 2019. MHR was calculated from the venous blood samples taken from each patient immediately before routine coronary angiography. Results: The study included 493 patients comprising 353 (71.6%) men and 140 (28.4%) women with a mean age of 63.03±10.88 years. Median follow-up period was 48 (interquartile range [IQR]: 26-73) months. Patients were divided into two groups: (I) MHR <17.68 (n=278) and (II) MHR ≥17.68 (n=215). Long-term mortality was significantly higher in group II than in group I (n=70, 32.6% vs. n=43, 15.5%; p<0,001). On multivariate logistic regression analysis, MHR was found to be an independent predictor of long-term mortality (Odds Ratio [OR]: 1.089, 95% Confidence Interval [CI]: 1.055-1.124, p<0,001). The Kaplan-Meier analysis showed lower survival rates in group II (MHR ≥17.68) than in group I (MHR <17.68) (75.223±2.670 vs. 89.220±2.102, p<0,001). Conclusion: MHR could be used as a practical universal biomarker of mortality and survival in CTO patients.