Introduction The aim of this study was to assess the impact of lymph node dissection (LND) on survival for patients with intermediate risk (IR) and high intermediate risk (HIR) endometrial cancer (EC). Methods Clinicopathologic features and survival data of 1294 consecutive patients who underwent primary surgical treatment for EC between 2003 and 2018 were were retrieved from the database of Hacettepe University Hospital. This study compared the overall survival (OS) and disease-free survival (DFS) among IR and HIR EC between patients with LND and no LND. Results The study population included 141 (55 %) IR, and 115 (45 %) HIR EC patients. LND was not performed in 33 (23.4%), and 31 (27%) patients in IR, and HIR EC patients, respectively. The lymph node involvement was 10.3% (n=20) among all patients. During the median follow-up of 41 months (range, 12–222), 12 (6.2 %) patients with LND, and 5 (7.8 %) patients without LND had disease recurrence (p=0.77). LND did not improve OS and DFS in IR and HIR EC patients (p=0.92, p=0.80). And the lymph node count was not associated with OS and DFS for all subsets of patients with EC grouped by recurrence risks. Discussion Without illuminating the morbidity of LND, there were no difference observed in OS and DFS between IR and HIR EC patients with LND-induced complications and no LND. With this regard, the use of sentinel lymph node procedure might be better for minimizing the possible post-operative morbidities in this selected patient groups.

Objective: To analyze the serum markers for the early diagnosis of intestinal anastomotic leak (AL) after the gyne-oncological operations. Methods: Between September 2017 and March 2021, patients with an intestinal anastomosis performed during the gyne-oncological surgeries were identified from a tertiary center in Turkey. As the local guideline of the clinic, all these patients were followed by measuring serum samples including procalcitonin (PCT) and C-reactive protein (CRP) on postoperative day (POD) 1 through the day of discharge or the day of re-operation for AL. Results: 12.5% (5/40) of the patients suffered an AL and 4 of them were re-operated. The mean albumin values on POD 3-4 and the mean platelet values on POD 1 were lower in the AL group (p<0.05). Although it was not statistically significant (p>0.05), median PCT values (ng/mL) on POD 8-10 were higher in the AL group compared with no leak group. The best cutt-off point for PCT on POD 9 was determined to be 0.11 ng/mL (AUC: 0.917, Sensitivity = %100.0, specifity = %66.7, positive predictive value = %66.7, negative predictive value = %100.0). Conclusion: Serum PCT and CRP concentrations were not found to be helpfull for the early diagnosis of AL in patients operated for gyne-oncological malignancies. Low levels of albumin and platelets in the first days after the operation may be clue for a possible AL.