Hemophagocytic lymphohistiocytosis is a rare condition, characterized by excessive cytokine release and inflammatory response. HLH can be primary or secondary to infections, neoplasm or autoimmune conditions. Management includes immunosuppressive agents. Diagnosis of HLH is difficult in the setting of sepsis. We report a case of Klebsiella pneumonia complicated by HLH.

Waldenström Macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is often differentiated from myeloma based on the presence of lytic bone lesions (LBL). However, WM/LPL can present with LBL and management is poorly understood. We describe a case of an 81-year-old woman with LPL who presented with LBL and was successfully treated with chemoimmunotherapy.