Background: Emerging evidence exhibited the importance of life quality of children with pediatric cancers and their parents. The child patients generally have poor life quality and pyschological status under the intensive comprehensive therapies. Procedure: The cultural and psychological program named Ward School Program (WSP) may ease the psychological stress for the child patients. The purpose of this study is to systemically evaluate the impact of the WSP on the quality of life and psychological behavior of children with pediatric cancers. We evaluated the life quality and negative emotions of the children and their parents individually. Results: 46 child patients and their parents have accepted the invitation. compared to the occasional participation group (OP), the WSP has significantly improved the life quality satisfaction, enhanced self-conception, and promoted learning ability and attitude of the In-depth participation group (IDP), while their parents have different opinions. The parents believe that the WSP could significantly improve children’s personality problems and relieve children’s anxiety, but it has not much help on their learning skills, it indicated that it is necessary to enhance communication between parents and children for better understanding of each other. Conclusion: The WSP have postive effects on the improvement of life quality and pyschosocial behaviors for the children with pediatric cancers.