Incidence density of influenza illness during pregnancy in Suzhou,
China, 2015--2018
Abstract
Background: Data on influenza incidence during pregnancy in China are
limited. Methods: From October 2015–September 2018, we conducted active
surveillance for acute respiratory illness (ARI) among women during
pregnancy. Nurses conducted twice weekly phone and text message
follow-up upon enrollment until delivery to identify new episodes of
ARI. Nasal and throat swabs were collected ≤10 days from illness onset
to detect influenza. Results: In total, we enrolled 18,724 pregnant
women median aged 28yo, 37% in first trimester, 48% in second
trimester and 15% in third trimester, with 7 self-reported vaccination
during pregnancy. In the 18-week epidemic period during October
2015–September 2016, influenza incidence was 0.7/100 person-months
(95% CI:0.5–0.9). In the 29-week epidemic during October
2016–September 2017, influenza incidence was 1.0/100 person-months
(95% CI:0.8–1.2). In the 11-week epidemic period during October
2017–September 2018, influenza incidence was 2.1/100 person-months
(95% CI:1.9–2.4). Influenza incidence was similar by trimester. More
than half of the total influenza illnesses had no elevated temperature
and cough. Most influenza-associated ARIs were mild, and
<5.1% required hospitalization. Conclusions: Influenza
illness in all trimesters of pregnancy was common. These data may help
inform decisions regarding the use of influenza vaccine to prevent
influenza during pregnancy.