Abstract
Background:The aim of the present study was to compare the operative and
early postoperative results of the use of del Nido Cardioplegia
solution(dNCS) with traditional blood cardioplegia(BC) in adult aortic
surgery. Methods: A retrospective single-center study was performed on
118 patients who underwent aortic surgery with cardiopulmonary bypass
(CPB) between January 2016 and June 2020. Patients were divided in to
two groups according to the type of cardioplegia solution used during
the operation. Cardiac arrest was achieved in Group 1(n:65) with
traditional BC and in Group 2(n=53) with dNCS. Operative and
postoperative outcomes of the patients were compared between the two
groups. Results: Patient demographic characteristics were similar
between the two groups. dNCS group showed significantly lower aortic
cross-clamp (ACC) time(87,5 vs 73,3 min; P=0.001), cardioplegia volume
(P<0.001), defibril¬lation(P=0.006), drenaige amount(P=0.026)
and inotropic support need (P=0.046).Also dNCS group had significantly
lower high sensitive troponin I (hsTnI) values at 6th
(P=<0.001) and 24th (P=0.017) hours. Hematocrit levels at
hours 6 and 24 were significantly higher in dNCS (P=0.001).Time of
intensive care unit stay, duration of extubation and length of hospital
stay times were similar in both groups. There was no significant
difference in terms of postoperative ejection fraction values(P=0.714).
Conclusion: Compared with conventional BC, dNCS provided beter
myocardial protection with significantly shorter ACC times, reduced need
for intraoperative defibrillation, postoperative lower hsTnI levels and
comparable early clinical outcomes for adult patients undergoing aortic
surgery. dNCS is a safe and efficient alternative to the traditional BC
solution in adult cardiac surgery.