Mechanism studies on the cellular internalization of nanoparticles using
computer simulations: A review
- Yun Hao Feng,
- Bo Zhi Chen,
- Wen Min Fei,
- Yong Cui,
- CAN YANG ZHANG,
- Xin Dong Guo
CAN YANG ZHANG
Tsinghua Shenzhen International Graduate School
Author ProfileAbstract
Nanomaterial drug delivery systems have become one of the most important
targeted therapy technologies. Although great efforts have been made to
study the self-assembled mesoscopic structure of nanoparticles and
understand drug loading and release mechanisms, the interaction between
nanoparticles and cell membranes has not yet been clearly studied.
Moreover, the research of experimental methods in this field has been
greatly restricted due to its special time-space scale, so it is
necessary to apply computer simulations to visualize the cell
internalization of the nanoparticle. This review covers modelling
methods and the current status and viewpoints of research on the
influencing factors of the nanoparticle-biomembrane interaction
mechanism. In particular, we discussed in detail the positive and
negative effects of various nanoparticle properties. This article may
assist researchers in rationally optimize the nanoparticle structure to
improve therapeutic efficiency.10 Jun 2021Submitted to AIChE Journal 26 Jun 2021Submission Checks Completed
26 Jun 2021Assigned to Editor
28 Jun 2021Reviewer(s) Assigned
03 Aug 2021Editorial Decision: Revise Minor
18 Aug 20211st Revision Received
28 Aug 2021Submission Checks Completed
28 Aug 2021Assigned to Editor
30 Aug 2021Reviewer(s) Assigned
10 Oct 2021Editorial Decision: Accept