Autoimmune Overload: An atypical presentation of granulomatosis with
polyangiitis in an adolescent with type-1 diabetes mellitus
Abstract
We report a case of granulomatosis with polyangiitis (GPA) in a
pediatric patient with a history of type 1 diabetes mellitus (T1DM)
after a somewhat unusual presentation. Antineutrophil cytoplasmic
antibody (ANCA)-associated vasculitides are a relatively rare entity in
the general population, and are even less common amongst the pediatric
population. Our patient’s chronic history of vague and systemic symptoms
paired with social and environmental stressors contributed to her
convoluted picture and late diagnosis. In addition, her T1DM adds an
interesting element to her case, begging the question of whether her
propensity for autoimmune conditions played a role in the development of
this disease. With this case, we hope to increase clinician level of
suspicion and promote early diagnosis and treatment for future pediatric
patients.