Challenge of Interpreting Cytoplasmic CD20 Stain in Diffuse Large B Cell
Lymphoma Biopsy Specimen of Patients with Steroid Usage
Abstract
Lymphoma work-up involves immunohistochemical stains to help reach the
diagnosis. It is imperative to have clinical information and sound
knowledge of staining pattern of antibodies to avoid misinterpretation
of results. We describe two cases in which pre-biopsy steroid hindered
antigenic profile, leading to “cytoplasmic granular staining” and
causing delay.
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