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Pediatric anterior larynx: presentations and associations
  • Hussein Smaily,
  • Ismaeel El-Hakim,
  • Hamdy El-Hakim
Hussein Smaily
University of Alberta

Corresponding Author:[email protected]

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Ismaeel El-Hakim
University of Alberta
Author Profile
Hamdy El-Hakim
University of Alberta
Author Profile

Abstract

Objective: The literature on the entity of the anterior larynx (AL) is restricted to little evidence on the difficulty encountered in exposing the larynx for intubation, perioperative morbidity and mortality, and scant reports on its prevalence in general adults and children. We here describe the prevalence of AL in a series of children presenting with aerodigestive symptoms and explore its association with functional abnormalities, congenital and structural anomalies or conditions. Setting: Tertiary pediatric center Methods: we conducted a retrospective case-control study. Using a prospectively collected surgical database we identified patients diagnosed with AL (grades IIb-III-IV Modified Cormack-Lehane scale) and sex and age-matched controls who had undergone full airway endoscopy for aerodigestive symptoms. We collected the demographics, presentations, associated diagnoses, and investigations. We compared the proportion of patients with large airway abnormalities and dysmorphism and estimated the prevalence of AL. Results: over a 5.5-year period, 58 children (28 females) were matched with 58 controls. Although both groups presented with permutations of stridor, respiratory failure, cyanotic spells, swallowing and feeding difficulties and SDB, AL presented much more with swallowing and feeding problems (33 vs 20, p<0.05). There were significantly more children with dysmorphism in the AL group (29 vs 9, P < 0.05). The prevalence of AL was 4.9%. Conclusions: This is the first study to report the prevalence of AL amongst a cohort of children with aerodigestive symptoms. Its significant association with dysmorphic features warrants genetic consultation. It is associated with swallowing abnormalities that justifies a systematic instrumental evaluation
14 Aug 2021Submitted to Clinical Otolaryngology
21 Aug 2021Submission Checks Completed
21 Aug 2021Assigned to Editor
22 Aug 2021Reviewer(s) Assigned
21 Sep 2021Review(s) Completed, Editorial Evaluation Pending
01 Oct 2021Editorial Decision: Revise Major
31 Oct 20211st Revision Received
08 Nov 2021Submission Checks Completed
08 Nov 2021Assigned to Editor
10 Nov 2021Reviewer(s) Assigned
12 Nov 2021Review(s) Completed, Editorial Evaluation Pending
14 Nov 2021Editorial Decision: Revise Minor
22 Nov 20212nd Revision Received
22 Nov 2021Submission Checks Completed
22 Nov 2021Assigned to Editor
25 Nov 2021Review(s) Completed, Editorial Evaluation Pending
27 Nov 2021Editorial Decision: Accept