Rheumatoid arthritis (RA) is an autoimmune multi-systemic inflammatory disease affecting joints result in dysfunction and ultimately damage, seronegative RA has the clinical manifestations but negative diagnostic markers of RA. A 24 years old male presented with bilateral knee swelling.

Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by symmetric and destructive polyarthritis with a broad spectrum clinical manifestation of various organs. Rheumatoid neutrophilic dermatitis (RND) is an unusual distinctive manifestation of RA and typically develops in severe RA. 51-year-old female presented with a skin rash involving her extremities.

SLE is a chronic autoimmune disease characterized by multisystem inflammation, Vesiculobullous (VB) are different groups of oral disorders characterized by the formation of bullae. The aim of this report is to describe a case of a vesiculobullous disease in SLE.