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Photoplethysmography for non-invasive diagnosis of cold urticaria
  • +10
  • Daria Fomina,
  • Sofia Serdotetskova,
  • Alexander Machikhin,
  • Mikhail Volkov,
  • Anastasia Guryleva,
  • Mojca Bizjak,
  • Valeriya Bukova,
  • Marina S. Lebedkina,
  • Gerelma Andrenova,
  • Olga Mukhina,
  • Mukatova Irina,
  • Inna Danilycheva,
  • Marcus Maurer
Daria Fomina
GBUZ Gorodskaa kliniceskaa bo'lnica No 52 Departamenta zdravoohranenia goroda Moskvy

Corresponding Author:[email protected]

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Sofia Serdotetskova
GBUZ Gorodskaa kliniceskaa bo'lnica No 52 Departamenta zdravoohranenia goroda Moskvy
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Alexander Machikhin
FGBUN Naucno-tehnologiceskij centr unikal'nogo priborostroenia Rossijskoj akademii nauk
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Mikhail Volkov
FGBUN Naucno-tehnologiceskij centr unikal'nogo priborostroenia Rossijskoj akademii nauk
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Anastasia Guryleva
FGBUN Naucno-tehnologiceskij centr unikal'nogo priborostroenia Rossijskoj akademii nauk
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Mojca Bizjak
Klinika Golnik
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Valeriya Bukova
FGBUN Naucno-tehnologiceskij centr unikal'nogo priborostroenia Rossijskoj akademii nauk
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Marina S. Lebedkina
GBUZ Gorodskaa kliniceskaa bo'lnica No 52 Departamenta zdravoohranenia goroda Moskvy
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Gerelma Andrenova
GBUZ Gorodskaa kliniceskaa bo'lnica No 52 Departamenta zdravoohranenia goroda Moskvy
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Olga Mukhina
GBUZ Gorodskaa kliniceskaa bo'lnica No 52 Departamenta zdravoohranenia goroda Moskvy
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Mukatova Irina
Astana Medical University
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Inna Danilycheva
NRC Institute of Immunology FMBA of Russia
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Marcus Maurer
Charite Universitatsmedizin Berlin
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Abstract

Background: Cold urticaria (ColdU) is a common type of chronic inducible urticaria. Patients with typical ColdU develop wheals in response to standard cold stimulation tests (CSTs), an ice cube (ICT) or TempTest ®. As of now, the evaluation of CST response is visual and subjective. Validated, robust, and objective test readouts lacking today are needed. Methods: We subjected 63 patients (39 with typical ColdU and 24 with atypical ColdU) and 15 healthy controls (HCs) to TempTest ® CSTs and critical temperature threshold assessments. Blood microcirculation photoplethysmography (PPG) measurements were performed 5 min before and 10 min after the ICT on the volar forearm. Results: PPG amplitudes reflected normal baseline skin blood perfusion in patients with typical or atypical ColdU. Ice cube CSTs induced a marked increase in blood perfusion and PPG amplitudes in typical but not atypical ColdU, with distinct pre-post CST changes in PPG amplitudes in the former. The ratio of post-provocation and baseline PPG amplitudes ( R PPG) in typical ColdU patients exceeded that in atypical ColdU patients and HCs more than 3-fold. Almost all typical ColdU patients (98%), but only 13% of atypical ColdU patients and 7% of HCs had R PPG >3. PPG results matched those of CSTs in 94% of all tested individuals. Conclusion: Photoplethysmographic assessments of CST responses appear accurate and provide objective readouts. PPG may be of use in diagnosing ColdU, distinguishing typical and atypical ColdU, and more precise threshold testing.