A new “single” era of biomedicine: Applications in cardiovascular
disease and COVID-19
Abstract
With the development of cellular, chemical, and molecular biology, such
as, single-cell, single-molecule, single-nucleus, single-chromosome and
other related biotechnologies for analysis of chromatin regions, and
under the help of single-nucleus and single-cell transcriptomics of
human diseases in cardiovascular system, there are many novel
breakthroughs in the field of life science and medicine. It can be said
that a new “single” era of biomedicine comes. As transforming medical
research tools at single-cell levels, single-cell technologies including
single-cell RNA sequencing (scRNA-seq) provide high-resolutions insight
into complex tissues covered cardiovascular and brain systems, they can
help to understand molecular mechanisms of both COVID-19 and
cardiovascular disease (CVD), such as atherosclerosis (AS), acute
myocardial infarction (AMI), arrhythmogenic cardiomyopathy (ACM),
inherited thoracic aortic aneurysm (iTAA) or ascending thoracic aortic
aneurysm (ATAA), calcific aortic valve disease, heart failure, and
others as well as develop novel therapeutic targets and approaches
relevant for CVD and COVID-19.