Exploring of the prognostic value of eight immunohistochemical markers
expressed in the tumor microenvironment and on Hodgkin Reed-Sternberg
cells in pediatric patients with classical Hodgkin lymphoma
Abstract
Immunohistochemical markers are associated with treatment outcome in
adults with classical Hodgkin Lymphoma (cHL). Studies in children are
scarce and inconsistent. We investigated in 67 children with cHL,
whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and
TARC is associated with the event-free survival (EFS) and the interim
remission status. Low expression of PD-L1 was significantly associated
with complete remission at interim PET-scan. There was no association
between marker expression and EFS. Our data suggest a difference between
pediatric and adult cHL. This underlies the importance of future
research into specific molecular drivers in pediatric cHL.