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Exploring of the prognostic value of eight immunohistochemical markers expressed in the tumor microenvironment and on Hodgkin Reed-Sternberg cells in pediatric patients with classical Hodgkin lymphoma
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  • Eline Zijtregtop,
  • Ilse Tromp,
  • Rana Dandis,
  • Christian Zwaan,
  • King Lam,
  • Friederike Meyer-Wentrup,
  • Auke Beishuizen
Eline Zijtregtop
Erasmus MC Sophia Children Hospital

Corresponding Author:[email protected]

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Ilse Tromp
Erasmus MC Sophia Children Hospital
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Rana Dandis
Princess Maxima Center for Pediatric Oncology
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Christian Zwaan
Princess Maxima Center for Pediatric Oncology
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King Lam
Erasmus Medical Center
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Friederike Meyer-Wentrup
Princess Maxima Center for Pediatric Oncology
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Auke Beishuizen
Princess Maxima Center for Pediatric Oncology
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Abstract

Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC is associated with the event-free survival (EFS) and the interim remission status. Low expression of PD-L1 was significantly associated with complete remission at interim PET-scan. There was no association between marker expression and EFS. Our data suggest a difference between pediatric and adult cHL. This underlies the importance of future research into specific molecular drivers in pediatric cHL.
11 Aug 2022Published in Pathology and Oncology Research volume 28. 10.3389/pore.2022.1610482