Diffuse large B-cell lymphoma in the mandible mimicking post-extraction
complication Presentation and a 5-year follow-up of a rare case report
Abstract
Non-Hodgkin lymphomas (NHLs) are a heterogeneous group of malignancies
originating from the lymphoid tissues, which can be differentiated by
distinct epidemiology, etiology, and clinical characteristics. They can
occur in the lymph nodes or as extranodal lesions. The vast majority of
extranodal oral NHLs are classified as diffuse large B-cell lymphomas
(DLBCL). They are usually found in the maxilla and they rarely occur in
the mandible. The aim of this paper was to report a case of NHL with
mandibular location by detailing its different clinical, radiological,
and histopathological aspects. Herein, we report a case of NHL in the
under chin region of the mandible in a 66-year-old male patient. The
first diagnosis was post-extraction complication with delayed bone
healing. The clinical and standard radiological examinations had no
pathognomonic features. However, left labio-chin hypoesthesia and CT
examination revealed a malignancy of the lesion without any precision.
After performing further diagnostic examinations, including a subsequent
biopsy, diagnosis of diffuse large B-cell lymphoma (DLBCL) was made. The
patient was therefore treated with chemotherapy and he showed a
satisfactory outcome for more than 5 years. Intraoral lymphomas may
mimic odontogenic lesions; hence it is important for the dentist to be
aware of the various manifestations of NHL to avoid delay and
inappropriate treatment strategies.