Hospitalization Rate of Respiratory Syncytial Virus associated Acute
Lower Respiratory Infection among Young Children in Suzhou, China,
2010-2014
Abstract
Background: Data on disease burden of respiratory syncytial virus (RSV)
associated acute lower respiratory infection (ALRI) among young children
are limited in China. This study aimed to estimate the hospitalization
rate of RSV-associated ALRI (RSV-ALRI) among children aged
0~59 months in Suzhou, China. Methods: We
retrospectively identified all hospitalized ALRI children aged
0~59 months in Suzhou University Affiliated Children’s
Hospital during January 2010 to December 2014. Detailed diagnosis and
treatment data were collected by individual medical chart review.
Referring to WHO influenza disease burden estimation method, we
estimated the hospitalization rate of RSV-ALRI among children aged
0~59 months in Suzhou, China. Results: Among 28,209 ALRI
cases, 19,317 (68.5%) were tested for RSV and the RSV positive
proportion was 21.3% (4,107/19,317). The average hospitalization rate
of RSV-ALRI for children aged 0~59 months was 14 (95%
confidence interval [CI]:14~14)/1,000
children-years, for children aged 0~5,
6~11, 12~23, and 24~59
months were 70 (95%CI: 67~73), 31 (95%CI:
29~33), 11 (95%CI: 10~12), and 3
(95%CI: 3~3) /1,000 children-years, respectively.
Conclusion: There is considerable RSV-ALRI hospitalization among
children aged 0~59 months, particularly among children
aged <1 years. An effective monoclonal antibody or vaccine is
urgently needed to address the substantial hospitalization burden owing
to RSV infection. Key words: Respiratory syncytial virus,
Hospitalization rate, Acute lower respiratory infection, Children, China