Comparison of del Nido cardioplegia and blood cardioplegia in isolated
coronary artery bypass surgery
Abstract
Purpose: Our study aimed to examine the impacts of blood
cardioplegia (BC) and del Nido cardioplegia (DNC) solutions, which we
used in isolated coronary artery bypass grafting, on early mortality and
major adverse events. Material and method: We retrospectively
analyzed 329 consecutive patients who underwent coronary artery bypass
grafting (CABG) operations in our clinic between January 2016 and
January 2020. Myocardial infarction, reoperation, cardiac tamponade,
stroke, renal failure, extracorporeal membrane oxygenator requirement,
and cardiopulmonary resuscitation were defined as major adverse events.
The group for which del Nido cardioplegia was used was named Group D,
and the group for which blood cardioplegia was used was named Group B.
Group D consisted of 181 (55%) patients, and Group B consisted of 141
(45%) patients. Results: No statistically significant
difference was determined between the groups regarding age, weight, body
surface area, gender, or EuroSCORE ( p=.615, p=.560,
p=.934, p=.365, p=.955, respectively). Although
there was no statistically significant difference between the groups in
terms of aortic cross-clamp time ( p=.712), the cardiopulmonary
bypass duration was longer in Group B ( p=.001). Even though the
incidence of stroke was higher in Group B ( p=.030), no
statistically significant difference was observed between the groups
regarding the total incidence of major adverse events, mortality,
mechanical ventilation time, length of stay in the intensive care unit,
or length of hospital stay ( p=.153, p=.130,
p=.689, p=.710, p=.613, respectively).
Conclusion: We found no significant difference in MAE,
mortality, duration of MV, ICU stay, or hospitalization in the DNC and
BC groups. We believe that both solutions can be used safely for cardiac
protection in the adult patient population.