Abstract
Coronavirus belonging to family Coronaviridae is a large group of
viruses causing respiratory and gastrointestinal diseases. The outbreak
of 2019-novel coronavirus (2019-nCoV) has created panic in the whole
world after being transmitted from Wuhan, China in December 2019. A
large number of people are affected throughout the world that forced a
solitary situation in the affected areas confining common people to
their homes to prevent its spread. Cellular receptor in humans for
2019-nCoV are found to be same as for SARS-CoV (Severe acute respiratory
syndrome coronavirus), the first human pandemic of 21st century,
however, 2019-nCoV is highly contagious, virulent and mutable than the
SARS-CoV. The most attractive site for vaccine development against
novel2019 coronavirus is the spike glycoprotein which is crucial for
receptor binding, membrane fusion via confirmational changes, virus
internalization, host tissue tropism or spike inactivation through
antibody induced destabilization. Severity and fatality of the current
scenario has provoked the health care workers, scientists and
pharmaceutical organizations to develop a vaccine to prevent its
hazardous effects and transmission. First outbreak was in March 2020
after which the number of affected reduced that created a sigh of relief
in the globe. Summer season was considered as one of the aspect
combating the severity of spread of virus. For last few days, suddenly a
huge outrage is capturing attention of the entire population of earth
endangering lives of people irrespective of their ages and communities.