We found a seroprevalence of anti-SARS-CoV-2 IgG of 77% in a population of Cameroonian pregnant women sampled 14 months after the start of the COVID-19 pandemic. This high exposure to the virus requires a rethinking of vaccine priorities in African countries. The value of vaccination against COVID-19 should be considered at the local level based on seroprevalence studies, but the expanded programme of vaccination interrupted during the pandemic should be resumed urgently.