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VENDOR INDEPENDENT MYOCARDIAL STRAIN REFERENCE VALUES IN CHILDREN
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  • Benjamin Acheampong,
  • David Parra,
  • Corey Havens,
  • David Jantzen,
  • Justin Godown,
  • Jonathan Soslow
Benjamin Acheampong
University of Nebraska Medical Center Department of Pediatrics

Corresponding Author:[email protected]

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David Parra
Vanderbilt Department of Pediatrics
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Corey Havens
Vanderbilt Department of Pediatrics
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David Jantzen
University of Nebraska Medical Center Department of Pediatrics
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Justin Godown
Vanderbilt Department of Pediatrics
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Jonathan Soslow
Vanderbilt Department of Pediatrics
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Abstract

Background Two-dimensional (2D) strain imaging has become an important tool in assessing subclinical myocardial dysfunction in children. However, there are no pediatric reference values for vendor independent strain software. The aim of this study was to estimate 2D strain values in a cohort of healthy children using Tomtec cardiac performance analysis (CPA), a vendor independent software. Methods Transthoracic echocardiograms of healthy pediatric outpatients (0-18yrs) were retrospectively analyzed from the Vanderbilt Pediatric Heart Institute using CPA. Cardiac assessment included global longitudinal strain (GLS), global longitudinal strain rate (GLSR), global circumferential strain (GCS), global circumferential strain rate (GCSR). Mean strain values with standard deviation (SD) are reported. The Wilcoxon rank sum test, linear regression and one-way analysis of variance were used to assess differences among the various groups. Results Among 142 children analyzed, 79 (56%) were male, and the median age was 5.5 (range, 0-18) years. The mean (SD) strain values were GLS -19.3 ± 3.4, GLSR -1.1 ± 0.22; GCS -24.7 ± 4.3, GCSR -1.5 ± 0.28. Age accounted for <8% of variation in GLS, GCS and GSCR. However, for GLSR, there was a statistically significant difference between younger and older age groups with higher GLSR in the younger age group. Age accounted for ~25% of variation in GLSR (R 2 = 0.25, P < 0.001). There were no significant differences in strain based on sex. Conclusion We report normal reference values in healthy children by age for strain using CPA. These values are necessary for the interpretation of 2D strain imaging for both clinical care and research.
06 Apr 2022Submitted to Echocardiography
06 Apr 2022Submission Checks Completed
06 Apr 2022Assigned to Editor
13 Apr 2022Reviewer(s) Assigned
06 May 2022Review(s) Completed, Editorial Evaluation Pending
10 May 2022Editorial Decision: Revise Major
24 Jun 20221st Revision Received
03 Aug 2022Assigned to Editor
03 Aug 2022Submission Checks Completed
03 Aug 2022Reviewer(s) Assigned
04 Sep 2022Review(s) Completed, Editorial Evaluation Pending
12 Sep 2022Editorial Decision: Revise Minor
03 Oct 20222nd Revision Received
12 Oct 2022Submission Checks Completed
12 Oct 2022Assigned to Editor
12 Oct 2022Reviewer(s) Assigned
30 Oct 2022Review(s) Completed, Editorial Evaluation Pending
14 Nov 2022Editorial Decision: Accept
Mar 2020Published in Journal of the American College of Cardiology volume 75 issue 11 on pages 1752. 10.1016/S0735-1097(20)32379-2