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Acute Soft Head Syndrome in Sickle Cell Anemia: Creating A Firm Approach
  • Mark Drew,
  • Derek Fladeland,
  • Roona Sinha
Mark Drew
University of Saskatchewan College of Medicine

Corresponding Author:[email protected]

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Derek Fladeland
University of Saskatchewan College of Medicine
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Roona Sinha
University of Saskatchewan College of Medicine
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Abstract

Sickle cell disease (SCD) is the most common inherited disease worldwide and presents with a myriad of complications1. A rare complication of SCD is acute soft head syndrome (ASHS). We present the case of a 14-year-old male with homozygous sickle cell anemia (HbSS) who presented with vaso-occlusive crisis (VOC) complicated by the peculiar development of a scalp mass. Magnetic resonance imaging (MRI) showed calvarium changes consistent with ASHS. Current literature lacks standardized management for such a complication. As such, we outline recommendations for imaging modalities, therapeutic interventions, and ongoing management based on this patient’s course over two years.