Abstract
Sickle cell disease (SCD) is the most common inherited disease worldwide
and presents with a myriad of complications1. A rare complication of SCD
is acute soft head syndrome (ASHS). We present the case of a 14-year-old
male with homozygous sickle cell anemia (HbSS) who presented with
vaso-occlusive crisis (VOC) complicated by the peculiar development of a
scalp mass. Magnetic resonance imaging (MRI) showed calvarium changes
consistent with ASHS. Current literature lacks standardized management
for such a complication. As such, we outline recommendations for imaging
modalities, therapeutic interventions, and ongoing management based on
this patient’s course over two years.