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The pathogenesis in organ fibrosis: focus on necroptosis
  • +13
  • Min Hao,
  • Xin Han,
  • Zhouhui Yao,
  • Mengting Zhao,
  • Mengyun Peng,
  • Kuilong Wang,
  • Qiyuan Shan,
  • Xianan Sang,
  • Xin Wu,
  • Lu Wang,
  • Lv Qiang,
  • Qiao Yang,
  • Yini Bao,
  • Haodan Kuang ,
  • Hongyan Zhang,
  • Gang Cao
Min Hao
Zhejiang Chinese Medical University

Corresponding Author:[email protected]

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Xin Han
Zhejiang Chinese Medical University
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Zhouhui Yao
Zhejiang Chinese Medical University
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Mengting Zhao
Guizhou University of Traditional Chinese Medicine
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Mengyun Peng
Zhejiang Chinese Medical University
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Kuilong Wang
Zhejiang Chinese Medical University
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Qiyuan Shan
Zhejiang Chinese Medical University
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Xianan Sang
Zhejiang Chinese Medical University
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Xin Wu
Zhejiang Chinese Medical University
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Lu Wang
Zhejiang Chinese Medical University
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Lv Qiang
Zhejiang Chinese Medical University
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Qiao Yang
Zhejiang Chinese Medical University
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Yini Bao
Zhejiang Chinese Medical University
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Haodan Kuang
Zhejiang Chinese Medical University
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Hongyan Zhang
Zhejiang Cancer Hospital
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Gang Cao
Zhejiang Chinese Medical University
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Abstract

Fibrosis is a common process of tissue repair response to multiple injuries in all chronic progressive diseases, which featured with excessive deposition of extracellular matrix. Actually fibrosis can occur in all organs and tends to be nonreversible with the progresses of the diseases. Different cells types in different organs are involved in the occurrence and development of fibrosis, i.e. hepatic stellate cell, pancreatic stellate cell, fibroblasts, myofibroblasts. Present studies have shown that several programmed cell deaths including apoptosis, autophagy, ferroptosis, and necroptosis were closely related to organ fibrosis. Among these programmed cell deathes type, necroptosis, an emerging regulated cell death type were regard as a huge potential target to ameliorate organ fibrosis. In this review, we summarized the role of necroptosis signaling in organ fibrosis, and collected the present small molecule compounds targeting necroptosis. In addition, we have discussed the potential challenges, opportunities and open questions in using necroptosis signaling as a potential target for antifibrotic therapies.
12 Apr 2022Submitted to British Journal of Pharmacology
20 Apr 2022Submission Checks Completed
20 Apr 2022Assigned to Editor
26 Apr 2022Reviewer(s) Assigned
23 Jun 2022Review(s) Completed, Editorial Evaluation Pending
30 Jun 2022Editorial Decision: Revise Minor
19 Jul 20221st Revision Received
22 Jul 2022Submission Checks Completed
22 Jul 2022Assigned to Editor
27 Jul 2022Review(s) Completed, Editorial Evaluation Pending
28 Jul 2022Editorial Decision: Accept