Comparative effect of magnesium sulfate and indomethacin to magnesium
sulfate only for Tocolysis in preterm labor in pregnant women in Kosar
Hospital, 2019-2021
Abstract
Background:Preterm labor is one of the most common pregnancy
complications, and it can have catastrophic effects, including preterm
birth and accompanying complications. This study’s objective is to
compare the efficacy of Magnesium Sulfate and Indomethacin vs Magnesium
Sulfate alone in avoiding preterm labor in pregnant women at Kosar
Hospital in2019–2021. Methods:In this interventional study, which was
conducted as a double-blind, randomized clinical trial on 200 pregnant
women with gestational ages ranging from24to32weeks who were referred to
Qazvin’s Kosar Hospital. Patients were divided into two equal groups and
given magnesium sulfate and indomethacin (group A)or magnesium sulfate
alone(group B).The data then was analyzed with SPSS statistical software
and statistical tests. Results:According to the study’s findings, the
average time interval between receiving the drug and childbirth in group
A was774.71+505.91hours and in group B it was545.77+503.32hours,which
was statistically significant (P0.05). Besides that, the mean
gestational age at the time of pregnancy termination was35.30+250weeks
in group A and35.03+2.65weeks in group B, which was not statistically
significant (P>0.05).The type of intervention, on the other
hand, had a significant relationship with the number of labors during
the first 7 days after starting the drug (P >0.05).
Conclusion:The results showed that magnesium sulfate and indomethacin
were more effective than magnesium sulfate alone in inhibiting and
delaying preterm labor.There were similarities in comparing the findings
of our study with other studies. Keywords:Preterm labor,Magnesium
Sulfate,Indomethacin Financial disclosures:None