We report a rare case of right ventricular angioleiomyoma in a 35-years old man diagnosed by multimodality imaging, including echocardiography, cardiac magnetic resonance imaging (CMR), Positron emissions tomography (PET) and Computer tomography angiography (CTA). The imaging results were finally confirmed by surgery. We present the clinical value of multimodality imaging in diagnosing cardiac angioleiomyoma.