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Risk factors for recurrent respiratory tract infections or acute respiratory failure in children with spinal muscular atrophy
  • Wenhui Guo,
  • Linghui Meng,
  • Ling Cao
Wenhui Guo
Capital Institute of Pediatrics

Corresponding Author:[email protected]

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Linghui Meng
Capital Institute of Pediatrics
Author Profile
Ling Cao
Capital Institute of Pediatrics
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Abstract

Introduction: Assessment of and intervention for sleep-disordered breathing and malnutrition are related to respiratory management for preventing recurrent respiratory tract infections (RRTIs) and acute respiratory failure (ARF) in children with spinal muscular atrophy (SMA). However, the specific standard has not been clarified. Purpose: The study aimed to obtain the risk factors and the predictive index for RRTIs and/or ARF in children with SMA. Methods: In this retrospective study, the differences in clinical characteristics in patients with or without RRTIs and ARF were compared, and binary logistic regression analysis was carried out. The best cutoff points of the positive predictive index were obtained. Results: Type 1 (OR = 4.12, 95% CI 1.30-13.07, P =.016) and apnea hypopnea index (AHI) (OR = 1.14, 95% CI 1.05-1.24, P =.001) were risk factors, while body mass index z score (BMIz) (OR = 0.68, 95% CI 0.49-0.94, P =.018) and mean pulse oxygen saturation (MSpO 2) (OR = 0.67, 95% CI 0.50-0.91, P =.010) were protective factors. The sensitivity and specificity of the standard of MSpO 2 < 96% and AHI > 10 events/h or BMIz < -1 with the occurrence of RRTIs and/or ARF were 0.513 and 0.957, respectively. Conclusion: SMA Type 1, BMIz, AHI and MSpO 2 should be used to estimate the risk for RRTI or ARF in children with SMA. MSpO 2 < 96%, and AHI > 10 events/h or BMIz < -1 should be used as the intervention standard.
29 Jun 2022Submitted to Pediatric Pulmonology
29 Jun 2022Submission Checks Completed
29 Jun 2022Assigned to Editor
01 Jul 2022Reviewer(s) Assigned
01 Aug 2022Review(s) Completed, Editorial Evaluation Pending
02 Aug 2022Editorial Decision: Revise Major
15 Sep 20221st Revision Received
26 Sep 2022Submission Checks Completed
26 Sep 2022Assigned to Editor
26 Sep 2022Reviewer(s) Assigned
05 Oct 2022Review(s) Completed, Editorial Evaluation Pending
05 Oct 2022Editorial Decision: Revise Minor
15 Oct 20222nd Revision Received
20 Oct 2022Submission Checks Completed
20 Oct 2022Assigned to Editor
20 Oct 2022Review(s) Completed, Editorial Evaluation Pending
20 Oct 2022Reviewer(s) Assigned
23 Oct 2022Editorial Decision: Accept